Physico-chemical and physic-mechanical characterization of polypeptide-k: A phyto-insulin for oral delivery
Varun Garg, Puneet Kaur, Sachin Kumar Singh and Monica Gulati
Lovely Professional University, India
: J Pharm Drug Deliv Res
Abstract
Polypeptide-k is an anti-diabetic protein isolated from dried seeds of the ripened fruits of Momordica charantia. In last one decade, extensive research has been carried out on polypeptide-k to explore its potential applications in the treatment of diabetes mellitus. It is widely marketed in combination or alone in the form of tablets in Malaysian as well as Indian markets. However, the physic-chemical and physico-mechanical properties of the drug remain unexplored hitherto. Our study, for the first time, reports the vital preformulation parameters of the peptide molecule. The knowledge of these parameters will not only support the formulation development and evaluation but will also help in compiling the monograph of this peptide drug
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