Predisposing factors associated with disturbance of Insulin and glucose homeostasis in patients with first episode psychosis treated with selected Antipsychotics

Rehmat Shah

Predisposing factors associated with disturbance of Insulin and glucose homeostasis in patients with first episode psychosis treated with selected Antipsychotics

Rehmat Shah

University of Peshawar, Pakistan

: J Pharm Drug Deliv Res

Abstract

Atypical Antipsychotic Drugs (AAPDs) are being widely prescribed to treat schizophrenia and bipolar disorder; however, metabolic abnormalities in such patients have remained a main focus in the recent research. AAPDs-naÃƒÂ¯ve patients with first episode psychosis were studied who received olanzapine, quetiapine, combination of olanzapine with antidepressants/antiepileptics or received risperidone to evaluate whether these atypical antipsychotics have any effects on the blood level of insulin and c-peptide, random blood glucose and body weight. The serum samples of patients were taken before the intake of the first dose who were followed for an average time period of 45.17 days for olanzapine, 39.4 days for olanzapine in combination with antidepressants, 40.4 days for quetiapine and 37.87 days for risperidone for any drug induced changes in insulin, c-peptide, random blood glucose and body weight. We found that 41.46% of the total population was addict, out of which 17.65 % showed disturbed insulin before treatment (DIBT), 23.53% disturbed insulin after treatment (DIAT), 42.86% disturbed glucose before treatment (DGBT), 41.18% disturbed glucose after treatment (DGAT) and 52.94% did not report. Similarly, 58.54% of the total population was non-addict, out of which 29.16% showed DIBT, 16.67% DIAT, 25% DGBT and 16.67% DGAT. It is not antipsychotics only but schizophrenia itself, narcotics, cigarette smoking and use of oral snuff may also be implicated as risk factors in the disturbance of insulin and glucose levels.