Preparation and pharmaceutical evaluation of acetaminophen nano-fiber tablets: Application of solvent-based electrospinning method for tabletting
Mami Hamori, Rina Amano, Yoko Fuse, Ayuko Ikemoto, Kei Ishizumi, Kanako Ishino, Megumi Goto, Asako Nishimura, Kazumasa Naruhashi and Nobuhito Shibata
Doshisha Women’s College of Liberal Arts, Japan
: J Pharm Drug Deliv Res
Abstract
I n this study, we described an application of the solvent-based electrospinning (ES) method, which is mainly employed in the textile industry, to the field of pharmaceutics. Using a modified ES instrument, nano-fiber sheet including acetaminophen (AAP, a model drug) was prepared. Where, Methacrylic Acid Copolymer S (MAC) was used as a base polymer to produce nano-fiber, and then three types of tablets were prepared and evaluated pharmaceutically. By attaching a conductor-rod made from stainless steel to the central part of nano-fiber-collection plate of the ES apparatus, MAC nano-fiber sheet with or without AAP could be produced effectively. In vitro release profiles of AAP from a tablet prepared by MAC nano-fiber with AAP (NFT), a tablet prepared by absorbing AAP to drug-free MAC nano-fiber (NFTfree) and a tablet prepared by semi-absorbing AAP to MAC nano-fiber (NFTsemi) showed controlled release aspects of AAP as compared to a conventional physical mixture. Moreover, these tablets showed pH and compressed forcedependent release profiles of AAP. In vivo pharmacokinetic study in rats after intra-duodenal administration of these tablets including MAC nano-fiber clearly demonstrated that application of nano-fibrotic technique based on the ES method is a useful one to expand drug delivery system. Moreover, tableting of MAC nano-fibers can be performed using a tableting machine without lubricants, and addition of Tween 20 into the nano-fiber enabled regulation of the release profile of AAP. Thus, the ES method reported here is a useful technique for the controlled-release of drugs and has wide-ranging potential for pharmaceutical applications.
Biography
Mami Hamori is, currently, a PhD student in Japan at Doshisha Women’s College of Liberal Arts (Department of Biopharmaceutics). Her research interests focus on the drug delivery systems using nano-fibers.
iye201@dwc.doshisha.ac.jp
