QCM-D as clinical diagnostics tool
Munawar Hussain
Tuebingen University, Germany
: J Electr Eng Electron Technol
Abstract
Apart from the QCM-D’s (Quartz Crystal Microbalance with Dissipation) outstanding potential for thrombosis and haemostasis in therapeutic directions and decisions, it is attractive as diagnostic tool for clinical challenges in the prospective of cost-effectiveness, robustness and straight forwardness. An important relevant example is Heparin induced thrombocytopenia (HIT) platelet aggregation diagnostics. For HIT today’s clinics rely on functional assays including HIPA tests (heparin induced platelet aggregation) and serotonin release tests. HIT assays are part of clinical diagnostics but these need high expertise in this area. Owing to tediousness, time consumption and costs such tests should not be performed in laboratories with limited experiences in this area. QCM-D has outstanding potential for HIT detection of destructive antibodies via using ultrasensitive thin films.
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