Role of laser ablation in the management of primary liver tumors
Hamzah Adwan
Universidade Nove de Julho, Brazil
: Res J Opt Photonics
Abstract
Hepatocellular carcinoma (HCC) is the most common primary tumor of liver. The treatment options for HCC are various such as liver transplantation, hepatectomy, and local ablative treatments. These local ablative treatments included microwave ablation (MWA), and laser-induced thermotherapy (LITT), which are suitable for small HCC lesions or unresectable tumors. Purpose: The aim of this retrospective study was to evaluate the MR-guided LITT in the treatment of HCC, mainly regarding to therapy response, survival rates, and complications. Materials and methods: This study included 53 patients (12 females and 41 men; mean age: 67.5 ± 8 years) with 75 HCC lesions, that were treated by 76 LITT sessions. LITT was performed in analgosedation, and as an outpatient procedure. The cases were analyzed according to diameter of tumors, ablation time, diameter of the post-ablation area, complete ablation, complications, local tumor progression (LTP), intrahepatic distant recurrence (IDR), overall survival (OS), and disease-free survival (DFS). Results: The mean preablation axial diameter of tumor was 2.4 ± 0.9 cm. The mean diameter of ablation area was 5.3± 1.8 cm. The mean ablation time was 16.7±7.4 min. The rate of complete ablation was 98.7% (74/75). The rates of LTP and IDR were 3.8% and 64.2%, respectively. The 1-, 3-, and 5-year OS rates were 96.2%, 54.7%, and 30.2%, respectively. The 1-, 2-, and 3-year DFS rates were 54.7%, 30.2%, and 17%, respectively. There were no treatment-related deaths or major complications among the patients. The rate of minor complications was at 7.9% (6/76). Conclusion: The results of this study show that LITT is safe and effective local treatment, which provides long OS time for HCC patients.
Biography
Hamzah Adwan is a medical doctor who graduated in 2021 from Goethe-University Frankfurt am Main, Germany, and is currently doing his residency in Radiology. He has been doing research since 2018 at the Department of Radiology at Goethe-University Frankfurt am Main in the field of Interventional Oncology under the supervision of Professor Thomas J. Vogl. He has presented his work at a number of conferences and society meetings such as the CIRSE, IMSCB, ECR, Deutscher Röntgenkongress, and IROS. In addition, he has won a number of awards and recognitions including second prize winner of the oral presentation at the clinical sciences section at IMSCB 2020, and Scholarship holder of ‚Die hellsten Köpfe für die Radiologie‘ (brightest minds of Radiology) at Deutscher Röntgenkongress 2019&2020. He was selected as ambassador of IMSSB 2021. More recently, his abstract to the IROS 2022 in Salzburg/Austria was selected to be one of the ten best abstracts presented at the congress.
