Sensitive voltammetric detection of Febuxostat at novel graphene based zinc oxide nanoflower composite sensor

Ankita Sinha and Rajeev Jain

Sensitive voltammetric detection of Febuxostat at novel graphene based zinc oxide nanoflower composite sensor

Ankita Sinha and Rajeev Jain

Jiwaji University, India

: J Pharm Drug Deliv Res

Abstract

A novel graphene/zinc nanoflower nano-composite modified glassy carbon electrode (GR/ZnOFs/GCE) based electrochemical sensor has been developed for the sensitive determination of a muscle relaxant drug febuxostat (FEB) in methyl alcohol. The developed sensor was characterized by scanning electron microscopy, square wave voltammetry, cyclic voltammetry electrochemical impedance spectroscopy, X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). It was found that the nanocomposite film of GR/ZnOFs on GCE exhibits excellent electro-catalytic activity towards febuxostate reduction in Britton Robinson buffer at pH 6.5. Detection of FEB at GR/ZnOFs/GCE enhanced the peak current and also lowers the reduction over potential. Various kinetic parameters affecting the monitored electro-catalytic response were investigated and optimized for febuxostate determination. Under optimized conditions the developed sensor shows linear response between increasing concentrations of FEB (10-400 ng mL-1) and cathodic current by square wave voltammetry with correlation coefficient (r2) of 0.9954. The applicability of proposed sensor is further extended to in vitro determination of the drug in pharmaceutical formulation and in waste water with an acceptable recovery and reproducibility. The fabricated (GR/ZnOFs/GCE) sensor holds great promise for simple and sensitive quantification of febuxostat using electro-analytical techniques.