Synthesis and characterization of chitosan nanoparticles in the pharmaceutical application

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F Damiri, A Laaraibi, I Charhouf, N Knouzi, A Bennamara and M Berrada

University Hassan II of Casablanca, Morocco

: J Pharm Drug Deliv Res

Abstract

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Nanoparticles have been widely studied for applications in drug release systems. To prevent a drug from rapid release, biodegradable polymers which serve as protective drug coatings, have been developed. Chitosan as a biodegradable and biocompatible polymer is extensively used as a carrier for encapsulation of drugs and biological substances in the pharmaceutical industry due to its ability in a drug controlled-release system, its solubility in aqueous acidic solution which avoids the use of hazardous organic solvents while fabricating particles, its cationic nature that allows ionic to crosslink with multivalent anions, the capacity of chemical crosslink applied by its amino groups and its mucoadhesive character of increasing residual time at the site of absorption. Emulsion crosslinking, coacervation/precipitation, ionic gelation methods are usually used in preparing chitosan nanoparticles. Water-soluble drugs can be loaded by using the emulsion crosslinking technique with high encapsulation efficiency. In this method, a water/oil (W/O) emulsion was prepared by emulsifying the chitosan aqueous solution in the oil phase and aqueous droplets were stabilized by using a suitable surfactant. The stable emulsion is then solidified by an appropriate crosslinking agent. Recent Publications 1. Jiannan Li, Xiangru Feng, Baichun Liu, Yingjie Yu, Leming Sun, et al. (2017) Polymer materials for prevention of postoperative adhesion. Acta Biomaterialia 61:21-40. 2. Jun Jie Wang, Zhao Wu Zeng, Ren Zhong Xiao, Tian Xie, Guang Lin Zhou, et al. (2011) Recent advances of chitosan nanoparticles as drug carriers. International Journal of Nanomedicine 6:765-774. 3. Avnesh Kumari, Sudesh Kumar Yadav and Subhash C Yadav (2005) Biodegradable polymeric nanoparticles based drug delivery systems. Colloids and Surfaces B: Biointerfaces 75(1):1-18. 4. Kreuter J (1994) Nanoparticles in colloidal drug delivery systems. New York, Marcel Dekker, Inc., 261-276. 5. Bodmeier R, H G Chen and O Paeratakul (1989) A novel approach to the oral delivery of micro- or nanoparticles. Pharm. Res. 6:413-417.

Biography

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F Damiri is currently pursuing his second year PhD in Polymers and Science Pharmaceuticals at the University of Hassan II-Casablanca, Morroco. The working title of his thesis is “Synthesis and characterization of nanoparticles based on polysaccharides for medical applications.” fouad.damiri@ outlook.fr