Synthesis of molecularly imprinted polymer based on iron magnetic nanoparticles for controlled delivery of doxorubicin in treatment of mouse kidney adenocarcinoma
Hamid Hashemi-Moghaddam, Milad Mahdi and Saeed Zavareh
: J Diagnos Tech Biomed Anal
Abstract
I n this research, firstly a magnetic nano drug based of molecular imprinting polymer was synthesized. Dopamine was used as monomer and magnetic iron nanoparticles are the core of this nano drug. Then adsorption and desorption of doxorubicin in vitro conditions were considered. In the next step, the operation of these magnetic nano drugs was analyzed according to these criteria: Histologic examination, tumor markers, tissue distribution of drug in the body by HPLC technique in a rat model. Tested Groups were included as, controls: Tumors with no treatment, sham: Tumors without medication and exposure to magnetic fields. First therapy Group: Tumors and injection of PBS solution containing the nanoparticles and free drug in the mouse model, second therapy Group: Tumors and medication by free Sunitinib, third therapy Group: Tumors treated with the drug nanoparticle-containing medication without exposure to magnetic fields, forth therapy Group: Tumors treated with the drug nanoparticles containing the drug and exposure to magnetic fields.
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