Synthesis of Star copolymers of pyridine-hyperbranched polyglyciodol (Py-HPG) core with multiarms of poly(e-caprolactone)-block- hyperbranched polyglycidol PCL-HPG for drug delivery system
Alaa Kadhim, Lance Twyman and Haishang Wang
Sheffield University, UK
Institute of Molecular and Cell Biology, Singapore
: J Pharm Drug Deliv Res
Ring opening polymerization was employed to prepare a new type of star polymers of hyperbranched polyglycidol (HPG) core with multiarms of PCL-HPG using the core-first method. Micelles formed from Py-HPG- PCL-HPG copolymers were investigated as a novel drug delivery system. The structure of the star copolymer was characterized using 1HNMR, GPC, DLS and TEM. Number of drug molecules that are different in size and hydrophobicity were encapsulated within the hydrophobic region of the micelle with good extent of loading. The cytotoxicity of the star copolymer was investigated with human breast adenocarcinoma (MCF-7) cell line. Py-HPG-PCL-HPG is non-toxic delivery system that can delivery verity of small and large drug molecules.