Targeting transcription factors by natural agents for cancer therapy

<p>Gautam Sethi</p>

Targeting transcription factors by natural agents for cancer therapy

Gautam Sethi

National University of Singapore, Singapore

: J Diagnos Tech Biomed Anal

Abstract

Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. I will briefly discuss the importance of STAT3 as a potential target for cancer therapy and also provide novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs.