The efficacy of aloe vera gel in post-procedural wound care after fractional 1550 nm erbium-doped fiber laser
Montree Udompataikul, Thep Chalermchai and Udomsak Boonnarisarangkoon
Srinakharinwirot University, Thailand
: J Plant Physiol Pathol
Abstract
Aim: The aim of this study is to evaluate clinical efficacy and the safety of aloe vera gel in post-procedural wound care after fractional 1550 nm erbium-doped fiber laser treatment. Material & Method: 30 Thai participants with mild to moderate, photoaging skin, categorized by Glogau’s classification were enrolled. All participants were treated with fractional 1550 nm erbium-doped fiber laser. After laser treatment, the participants randomly assigned to apply one side with aloe vera gel and contralateral side with placebo. Clinical erythema score, erythema index, melanin index by Mexameter, transepidermal water loss (TEWL) by Tewameter and skin capacitance by Corneometer were assessed. The daily self-assessment report for wound recovery and global satisfaction score for treatment were assessed by participants. This study was followed for five visits, at the baseline, immediately after laser, at day three, day seven and day 14. Result: Aloe vera group showed significantly better improvement for clinical erythema score than the placebo at day three and day seven after laser (p-value=0.005 and 0.011, respectively). Aloe vera group also showed significantly lower transepidermal water loss (TEWL) than the placebo at day seven and day 14 after laser (p-value=0.03 and 0.04, respectively). Therefore, aloe vera group showed significantly better global satisfaction score than the placebo at day seven and day 14 after laser (p-value=0.05 and 0.05, respectively). However, there was no significant difference between two groups for erythema index, melanin index and skin capacitance. Median duration of wound recovery showed no difference between the two groups (six days vs. seven days, p=0.11). Conclusions: Aloe vera gel for post-procedural wound care after fractional 1550 nm erbium-doped fiber laser treatment is highly effective for the reduction of skin redness and the preservation of transepidermal water loss or skin barrier function with better global satisfaction score. Aloe vera gel could be considered as an alternative treatment.
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