Triamcinolone acetonide dry powder inhalation: A new approach for treathing asthma

Mine Ozyazici, Aysu Yurdasiper and Mesut Arici

Triamcinolone acetonide dry powder inhalation: A new approach for treathing asthma

Mine Ozyazici, Aysu Yurdasiper and Mesut Arici

Ege University, Turkey

: J Pharm Drug Deliv Res

Abstract

Introduction: Drug delivery by inhalation is routinely employed for the treatment of localized diseases such as asthma and other pulmonary conditions. Dry powder inhalers (DPIs) are pharmaceutical dosage forms of increasing popularity which are considered one of the important delivery devices capable of delivering respirable drugs to the lungs. Inhaled corticosteroids (ICSs) are effective in controlling inflammation and improving lung function and asthma symptoms and are recommended as first-line therapy for asthma patients. There is considerable evidence that treatment with antiinflammatory ICSs reduces morbidity and mortality in asthma. The objective of this study was to develop triamcinolone acetonide (TA) dry powder inhalers using spray drying and characterize the powder in terms of aerolization, flow and dissolution properties in order to determine which formulations could be the most suitable for pulmonary delivery. Preparation & Characterization: Mannitol (50%) and leucine (10, 20 and 30%) were dissolved in 20 ml distilled water. 250 mg TA was dissolved in 2 ml of acetone, added into 20 ml mannitol and leucine solution. The mixture was then spray-dried with constant stirring using a BÃƒÂ¼chi nanospray dryer B-90 (BÃƒÂ¼chi Laboratory-Techniques, Flawil, Switzerland). The formulations were characterized using scanning electron microscopy, zeta potential, X-ray powder diffraction, fourier-transform infrared spectroscopy, differential scanning calorimetric, thermogravitational, tapped density analysis. The in vitro aerosolization performance was investigated using next generation impactor (Copley). Result & Discussion: The optimized formulation developed in this study exhibits good in vitro aerosolization properties. According to FTIR analysis, there were no changes in the structure of TA induced by spray drying process. SEM images of DPI formulations showed almost good structures with particle size 1-5 ÃŽÂ¼m. A dry powder prepared by spray-drying offered great promise as a formulation for the lung delivery of TA.