Cytopathology is a branch of pathology which deals with the study of individual or free cells or tissue fragments in the disease which is extracted from tissues. Diagnostic techniques are used, which examines cells from various sites of the body which finally determines the exact cause or the nature of disease. In other words Cytopathology is the study of individual cells in disease. In contrast whole tissues are examined in the histopathology. Cytopathology is generally used to investigate diseases involving a wide range of body sites, often to aid in the diagnosis of cancer, but also in the diagnosis of some infectious diseases and other inflammatory conditions. For cytopathologic analysis, there are two methods for collecting cells: Exfoliative cytology method and Intervention cytology method.