Journal of Clinical Genomics

About Genome-Scale

A genome-scale metabolic network of chemical reactions which take place inside a living organism is primarily reconstructed from the information that is present in its genome and involves steps such as functional annotation of the genome, identification of the associated reactions and determination of their stoichiometry, assignment of localization, determination of the biomass composition, estimation of energy requirements, and definition of model constraints. This information can be integrated into a stoichiometric model of metabolism which can be used for detailed analysis of the metabolic potential of the organism using constraint-based modeling approaches and hence is valuable for understanding its metabolic capabilities.

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