Journal of Chromatography Research

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About Liquid chromatography–mass spectrometry

Liquid chromatography–mass spectrometry

Liquid chromatography–mass spectrometry (LC-MS) is one of the analytical techniques. It is most often cited technique for the liquid chromatographers. This technique combines the resolving power of liquid chromatography with the detection specificity of mass spectrometry. Liquid chromatography (LC) introduces sample components into the mass spectrometer (MS) by separating them. The MS ionises the molecule and detects charged ions. Mass spectrometry provides structural identity of the individual components with high molecular specificity and detection sensitivity & liquid chromatography separates mixtures with multiple components. This spectroscopic technique is being used to analyze inorganic, organic, and biochemical compounds, commonly found in complex samples of biological and environmental origin.

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