Journal of Chromatography Research

About Supercritical Fluid Chromatography

Supercritical Fluid Chromatography (SFC) is a form of normal phase chromatography, first used in 1962, which is used for the analysis and purification of low to moderate molecular weight, thermally labile molecules. It can also be used for the separation of chiral compounds. Principles are similar to those of high performance liquid chromatography (HPLC), however SFC typically utilizes carbon dioxide as the mobile phase; therefore the entire chromatographic flow path must be pressurized. Because this supercritical phase of being pressurized situation represents a state in which liquid and gas properties meets, it is sometimes called as “convergence chromatography”.

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