International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovasc Res Vol: 3 Issue: 3

Sildenafil Improves Exercise Capacity in Heart Failure: A Meta-Analysis (SIC Heart Study)

Matulac MO*, Macapugay LFP, Reyes MJT, Tumabiene KD and Mondragon A
Department of Cardiology, UP-Philippine General Hospital, Pasay City, Philippines
Corresponding author : Department of Cardiology
UP-Philippine General Hospital, #74C, Jose Street, Malibay, Pasay City, Philippines 1300
E-mail: [email protected]
Received: May 02, 2014 Accepted: June 19, 2014 Published: June 24, 2014
Citation: Matulac MO, Macapugay LFP, Reyes MJT, Tumabiene KD, Mondragon A (2014) Sildenafil Improves Exercise Capacity in Heart Failure: A Meta-Analysis (SIC Heart Study). Int J Cardiovasc Res 3:3. doi:10.4172/2324-8602.1000170

Abstract

Sildenafil Improves Exercise Capacity in Heart Failure: A Meta-Analysis (SIC Heart Study)

Background: Development of new forms of intervention to improve overall cardiac performance for heart failure remains to be a continuing challenge. Majority of patients with left ventricular dysfunction are dependent on pulmonary vascular resistance and right ventricular performance, parameters that are also important determinants of exercise and functional capacity. Sildenafil, a selective 5-phosphodiesterase inhibitor, is a proven effective therapy for primary and secondary pulmonary arterial hypertension. We conducted this meta-analysis to investigate the role of Sildenafil in lowering pulmonary arterial pressure and improving exercise capacity among patients with systolic heart failure complicated by pulmonary hypertension.

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