International Journal of Cardiovascular ResearchISSN: 2324-8602

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Review Article, Int J Cardiovasc Res Vol: 2 Issue: 4

Troponin and Tropomyosin in the Cardiomyocyte Nucleus:What for?

Faizal Z. Asumda*
Saint James School of Medicine, Chicago, USA
Corresponding author : Faizal Z. Asumda
Saint James School of Medicine, Chicago, USA
Tel: 786-942-9772
E-mail: [email protected]
Received: May 11, 2013 Accepted: July 24, 2013 Published: July 31, 2013
Citation: Asumda FZ (2013) Troponin and Tropomyosin in the Cardiomyocyte Nucleus: What for? Int J Cardiovasc Res 2:4. doi:10.4172/2324-8602.1000137

 

Abstract

 Troponin and Tropomyosin in the Cardiomyocyte Nucleus:What for?

 

A number of recent reports have shown the nuclear expression of troponin and tropomyosin in cardiac myocytes. This challenges the long standing view that these sarcomere proteins are physiologically restricted to the cytoplasm. A synthesis of the available data suggests that troponin and tropomyosin in the cell nucleus is not the result of cytoplasmic contamination. The data is suggestive of physiological roles outside their well-recognized function in excitation-contraction coupling.

Keywords: Troponin; Tropomyosin; Actin; Mesenchymal stem cells;Cardiomyocytes; Nucleus; Calcium

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