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Cell Biology: Research & Therapy

Editorial

Are Cancer Stem Cells Responsible for Cancer Recurrence?

Chelsea Grimes1, David A. Margolin2 and Li Li1*
1Laboratory of Translational Cancer Research, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
2Department of Colon Rectal Surgery, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
Corresponding author : Dr. Li Li
Laboratory of Translational Cancer Research, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
Tel:
504-842-2428; Fax: 504-842-3381
E-mail: lli@ochsner.org
Received: June 12, 2012 Accepted: June 13, 2012 Published: June 15, 2012
Citation: Grimes C, Margolin DA, Li L (2012) Are Cancer Stem Cells Responsible for Cancer Recurrence? Cell Biol: Res Ther 1:1. doi:10.4172/2324-9293.1000e102

Abstract

Are Cancer Stem Cells Responsible for Cancer Recurrence?

Local recurrence or distant organ metastasis are the major causes of cancer mortality. Conventional treatments, including surgery, chemotherapy, and irradiation, do not consistently prevent cancer recurrence. Thus, an alternative therapeutic approach is needed. Recent evidence indicates a specific cell population of cancer stem cells or tumor initiating cells (jointly CSC) exists in various cancers that may be identified by cell surface markers, such as CD133, CD44, aldehyde dehydrogenase 1 (ALDH1) enzyme expression, or side population. 

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