Southern California College of Optometry, USA view all
The International Journal of Ophthalmic Pathology (IOPJ) promotes rigorous research that makes a significant contribution in advancing knowledge in the fields of ophthalmology and also concentrates on the histopathological diagnosis, surgical and treatment methods for various eye disorders.
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Marcos Rogerio Sgrignoli, Letícia Yamasaki, Osimar de Carvalho Sanches, Rogério Giuffrida, Claudia Lizandra Ricci, Gabriela de Campos Santos, Heloisa Ferreira Duarte do Valle, Luis Felipe da Costa Zulim, Daniele Alves Silva,
Karina Maria Basso, Mariele Catherine Alves Silva and Silvia Franco Andrad
Comparison of Topical 0.03% Tacrolimus in Almond and Linseed Oil to Treat Experimentally Induced Keratoconjunctivitis Sicca in Rabbits
Keratoconjunctivitis sicca (KCS), or dry eye syndrome, is a common inflammatory disease of the ocular surface in animals and humans that is characterized by quantitative and/or qualitative tear change. The quantitative alterations are due to an aqueous component deficiency, and the qualitative alterations are due to a lipid or mucin layer deficiency that results in the instability of the pre-corneal tear film.
was observed in an otherwise clear cut case of abusive head trauma with bilateral retinal hemorrhage, optic nerve sheath hemorrhage and peripapillary intrascleral hemorrhage. Review of 60 archival cases of suspected abusive head trauma identified two more examples of extramedullary hematopoiesis in abusive head trauma that initially had been diagnosed as uveitis. Extramedullary hematopoiesis of the choroid may have a relation to premature birth, possible anemia or may be a reaction to intraocular bleeding due to earlier trauma. Choroidal extramedullary hematopoiesis may easily be confused for choroiditis and interpreted as a sign of infectious disease. Awarenes of the possibiliy of extramedullary hematopoiesis of the choroid should prevent misdiagnosis.
Detection of Diabetic Retinal Neuropathy Using Standard Clinical Electrodiagnostic Testing
Diabetes can lead to many systemic complications that include the nervous and renal systems. The vision of individuals with diabetes may be affected psychophysically, as noted with changes in dark adaptation, contrast sensitivity, glare recovery, color vision, and visual acuity [3-10]. The primary ocular complication of diabetes is diabetic retinopathy—one of the leading causes of blindness in American adults.
We report a very rare case with recurrent pterygium with cilia mimicking ectopic cilia. The history of the patient revealed prior pterygium excision operations. A slit-lamb examination revealed the recurrent pterygium with cilia in the nasal region. In the nasal region, the caruncular tissue which normally has cilia dragged by the residual base of the pterygium may be speculated to ectopic cilia.
Cold Atmospheric Plasma (CAP) has been shown to influence tissue wound healing but little is known about the impact of CAP on healthy corneal tissues and their ability to respond to injuries. The objective of this study is to examine the effect of CAP on wound healing after corneal epithelial and basement membrane ablation in New Zealand white rabbits. The rabbits were assigned into three groups. Ten Rabbits from two groups underwent a 6 mm corneal ablation to the right eyes. After ablation, five rabbits in group (A) received 2 minutes of CAP whereas the other five rabbits (B) were not treated with CAP. A third group (C) included two rabbits and received CAP without ablation. Eyes monitored for corneal haze,
epithelial healing, lens clarity and any signs of inflammation. At 24 hours, two rabbits from group A and two from group B were sacrificed to harvest the corneas. Twenty days, all remaining rabbits in groups A, B, and C were sacrificed and corneas were harvested. Corneas were fixed in formalin and stained with H&E or used for immunofluorescence microscopy to assess scar formation using antibodies against fibronectin and a-smooth muscle actin. At 24 hours, corneas from group A had average epithelial defect
of 9.25 mm2 on day 1 whereas those from group B had average defect of 12.05 mm2, a difference of 2.8 mm2 (P=0.57). H & E stained corneal sections didn’t show abnormal responses to injury at 24 hours and 20 days. Epithelial thickness and stromal cell counts 20 days after injury showed no significant differences. Analysis of immunofluorescence microscopy images showed no differences between all groups. In conclusion, CAP application to cornea doesn’t appear to have obvious adverse effects. CAP
does not interfere with rate of wound closure or induce increased inflammation. CAP did not have an effect on corneal wound healing or lead to scar formation.