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Journal of Liver: Disease & Transplantation
Editor-in-chief: Maxwell M. Chait, MD
Columbia University College of Physicians and Surgeons, USA  View Full Editorial Board
ISSN: 2325-9612
NLM ID: 101606490
Frequency: Biannual
Impact Factor: 0.28*
 
 
Journal of Liver: Disease & Transplantation (JLDT) is a peer-reviewed scholarly journal and aims to publish the most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of liver pathology and making them available online freely without any restrictions or any other subscriptions to researchers worldwide.
 

Journal of Liver: Disease & Transplantation primarily focuses on the topics:

  • Liver Studies
  • Liver Pathology
  • Liver Genetics
  • Autoimmune Liver Diseases
  • Liver Failure
  • Liver Transplantation
  • Viral Hepatitis
  • Viral Transplantation
  • Transplantation Outcomes
Any other material of Liver Diseases and Liver Transplantation relevance will also be considered.

The Journal is using Editorial Manager System for quality in review process. Editorial Manager is an online manuscript submission, review and tracking system. Review processing is performed by the editorial board members of Journal of Liver: Disease & Transplantation or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.

 
Interested authors are encouraged to submit manuscripts  through Online Submission System or Editorial Manager or send as an e-mail attachment to the Editorial Office at editor.jldt@scitechnol.com or editor.jldt@scitechnol.org
 
Journal of Liver: Disease & Transplantation  is organizing & supporting 3rd International Conference on Gastroenterology & Urology  during July 28-30, 2014 San Francisco, USA with the theme of Accelerating New Research and Technologies in Gastroenterology and Urology.

 *Unofficial 2014 Impact Factor was established by dividing the number of articles published in 2012 and 2013 with the number of times they are cited in 2014 based on Google search and the Scholar Citation Index database. If ‘X’ is the total number of articles published in 2012 and 2013, and ‘Y’ is the number of times these articles were cited in indexed journals during 2014 than, impact factor = Y/X

 
Current Issue
Hepatitis C: Success, but at a High Cost of Cure   Editorial
Maxwell M Chait
J Liver: Dis Transplant 2014    doi: 10.4172/2325-9612.1000e106
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Hepatitis C: Success, but at a High Cost of Cure

Hepatitis C is a chronic infection that afflicts approximately 170 million people worldwide with annual mortality of 350,000. There are approximately 15,000 deaths annually in the US. The US Food and Drug Administration (FDA) has recently approved the combination medication Ledipasvir/Sofosbuvir under the trade name of Harvoni with dramatically higher cure rates with fewer side effects than the interferon and ribavirin based regimens. The breakthrough treatment comes at a price that may place it out of reach for all but the wealthiest or best-insured patients.

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Sexual Dysfunction in Males with End-Stage Liver Disease: Partial Recovery after Liver Transplantation   Review Article
Julio CU Coelho, Alexandre CT de Freitas, Jorge EF Matias, Alcindo Pissaia Jr., Josť L de Godoy and Jo„o OV Zeni
J Liver: Dis Transplant 2014, 3:2    doi: 10.4172/2325-9612.1000122
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Sexual Dysfunction in Males with End-Stage Liver Disease: Partial Recovery after Liver Transplantation

Sexual dysfunction occurs in 70% to 89% of males with end-stage liver disease and reduces significantly the quality of life of the patient and his partner. The pathogenesis is multifactorial and includes hypothalamic-pituitary-gonadal axis dysfunction, psychological stress, associated diseases and use of medications. Hypogonadism is more pronounced in patients with alcoholic cirrhosis and primary hemochromatosis. Sexual dysfunction correlates with the intensity of hepatic dysfunction and is more pronounced in patients with higher Child-Pugh or MELD scores. Although successful liver transplant may improve erectile function and libido, sexual dysfunction frequently persists in many patients. Additional risk factors such as diabetes, arterial hypertension, smoking, alcohol intake, and psychological stress should be identified and adequately treated in order to reduce sexual dysfunction.

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Endovascular Treatment of Symptomatic Intrahepatic Portosystemic Venous Shunt Using Amplatzer Vascular Plug II   Case Report
Vinko Vidjak, Karlo Novačić, Jelena Popić Ramač and Maja Grubelić Crnčević
J Liver: Dis Transplant 2014, 3:2    doi: 10.4172/2325-9612.1000123
Preview

Endovascular Treatment of Symptomatic Intrahepatic Portosystemic Venous Shunt Using Amplatzer Vascular Plug II

Spontaneous intrahepatic portosystemic venous shunt (IPSVS) is a rare condition that implies abnormal communication between portal and systemic venous system within the liver parenchyma. It can be asymptomatic or present with symptoms of hepatic encephalopathy. We show a case of 74-year-old female patient with symptomatic IPSVS and successful endovascular treatment using Amplatzer Vascular Plug (AVP) II.

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RIO Kinase 3 over Expression Promotes Hepatocellular Carcinoma Invasion through Induction of Epithelial- Mesenchymal Transition and a Potential Link to WNT/β-Catenin Pathway Activation   Case Report
Trina Das, Sajida Hassan, Qinghua Feng, David Gretch, Jorge D Reyes and James D Perkins
J Liver: Dis Transplant 2014, 3:2    doi: 10.4172/2325-9612.1000124
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RIO Kinase 3 over Expression Promotes Hepatocellular Carcinoma Invasion through Induction of Epithelial-Mesenchymal Transition and a  Potential Link to WNT/β-Catenin Pathway Activation

Recurrence is a major cause of mortality for patients with hepatocellular carcinoma (HCC) following liver transplantation. We previously identified RIOK3 as a prominently expressed gene in HCC tumors that recurred following transplantation. This is consistent with findings of increased RIOK3 expression in metastatic head, neck, and pancreatic cancers, which suggests RIOK3 is involved in cancer recurrence. In this study, we aimed to determine the pathway leading to HCC tumor invasion induced by RIOK3.

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A Case of Resected Cholangiolocellular Carcinoma during Treatment for Lung Cancer   Case Report
Masaru Inagaki, Koji Kitada, Naoyuki Tokunaga, Kenji Takahashi, Ryosuke Hamano, Hideaki Miyaso, Yosuke Tsunemitsu, Shinya Otsuka and Hiromi Iwagaki
J Liver: Dis Transplant 2014, 3:2    doi: 10.4172/2325-9612.1000125
Preview

A Case of Resected Cholangiolocellular Carcinoma during Treatment for Lung Cancer

Cholangiolocellular carcinoma is an extremely rare malignant primary liver tumor, accounting for less than 1% of primary liver tumors. We herein report a case of cholangiolocellular carcinoma during treatment for lung cancer. A woman following up after operation for lung cancer was found to have a solitary hepatic tumor in the left lobe of the liver at an abdominal computed tomography checkup. It showed early enhancement with hypovascular area of the center in the arterial phase and enhancement contrast retention in the delayed phase. The tumor was seen as a hypointense nodule in the hepatocellular phase of EOB magnetic resonance imaging. We diagnosed liver metastasis of lung cancer with differential diagnosis of cholangiocellular carcinoma. We performed extended left lobectomy of the liver. Histological and immunohistochemistry findings were compatible with cholangiolocellular carcinoma./p>

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