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Journal Highlights
Journal of Liver: Disease & Transplantation
Editor-in-chief: Maxwell M. Chait, MD
Columbia University College of Physicians and Surgeons, USA  View Full Editorial Board
ISSN: 2325-9612
NLM ID: 101606490
Frequency: Biannual
Impact Factor: 0.28*
Journal of Liver: Disease & Transplantation (JLDT) is a peer-reviewed scholarly journal and aims to publish the most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of liver pathology and making them available online freely without any restrictions or any other subscriptions to researchers worldwide.

Journal of Liver: Disease & Transplantation primarily focuses on the topics:

  • Liver Studies
  • Liver Pathology
  • Liver Genetics
  • Autoimmune Liver Diseases
  • Liver Failure
  • Viral Hepatitis
  • Liver Transplantation
  • Transplantation Outcomes
  • Post transplantaion Care
Any other material of Liver Diseases and Liver Transplantation relevance will also be considered.

The Journal is using Editorial Manager System for quality in review process. Editorial Manager is an online manuscript submission, review and tracking system. Review processing is performed by the editorial board members of Journal of Liver: Disease & Transplantation or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.

Interested authors are encouraged to submit manuscripts  through Online Submission System or Editorial Manager or send as an e-mail attachment to the Editorial Office at or

Liver Biology

Liver is the glandular organ that stores and metabolizes nutrients, detoxifies, and produces bile salts. Liver is the largestorgan of human body. The study of anatomy and functions of the liver is known as Liver Biology.

Liver Physiology

The study of functions and activitiesof the liver is known as Liver Physiology. It also dealswith the way in which the Liver and itsparts function

Liver Functions

Functions of the liver include:

Production of Bile,  which helps carry away waste and break down fats in the small intestine during digestion,

Production of proteins for blood plasma and detoxification of blood.




Hepatology is the branch of medicine that incorporates the study, prevention and diagnosis of liver, gallbladder, biliary tree, and pancreas as well as management of their disorders but is not limited to, the study of acute and chronic hepatitis, viral hepatitis, genetic and metabolic liver diseases and their complications.

Translational Hepatology

The fundamental concept underlying the Translational Hepatology is that human disease can serve as a window into broad biological processes, the understanding of which could, in turn, lead to treatments for these and other diseases.

Liver Pathology

The study of Liver diseases is called Liver pathology. Liver diseases can be inherited or caused by a variety of factors that damage the liver, such as viruses and alcohol use. Liver diseases include the following conditions: Cirrhosis, Inflammation or hepatitis.

Liver Disease Diagnosis

Liver disease can often be difficult to diagnose because its symptoms can be vague and easily confused with other health problems. Blood tests can look for the presence of liver inflammation or screen for antibodies or virus particles that might indicate a specific form of liver Disease. These tests are called Liver Tests.

Liver Disease Complications

These include high blood pressure in the veins that supply the liver, swelling inthe legs and abdomen, enlargement of spleen, bleeding, infections, malnutrition, jaundice, bone diseases, increased risk of liver cáncer and acute-or-chronic cirrosis.

Immunology of Hepatobiliary systems

The hepatobiliary system is essential for digestion and includes: the liver, pancreas, bile ducts and the gallbladder. Many disorders and diseases can affect these organs of hepatobiliary system. Immunology deals with the defence mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc.


The medical specialty devoted to the study, diagnosis and treatment of disorders of the digestive system. These disorders may affect the esophagus (swallowing tube), stomach, small intestine, large intestine (colon), rectum, liver, gallbladder, or pancreas.

Digestive Disorders

Digestive disorder is any health problems that occurs in the digestive tract. Some common problems include Heart burn/GERD, Irritable bowel syndrome and Lactose intolerence. Symptoms may include Bloating, diarrhoea, gas, stomach pain and stomach cramps.

Liver Cancers

It is also known as Hepatic Cancer, which starts in the liver. It is a condition that happens when normal cells in the liver become abnormal and grow out of control into cáncer.

Liver Cirrhosis

Cirrhosis is a slowly progressing Disease in which healthy liver tissue is replaced with scar tissue, eventually preventing liver from functioning properly. The scar tissue blocks the flow of blood through the liver and slows the processing of nutrients, hormones, drugs and naturally produced toxins.

Liver Hepatitis

Hepatitis is swelling and inflammation of liver. Hepatitis is most commonly caused by viral infection. Other causes of Hepatitis include autoinmune hepatitis (a disease occuring when the body makes antibodies against the liver tissue) and hapatitis that occurs as a secondary result of medications, drugs, toxins and alcohol.

Liver Failure

Liver failure is a life threatening condition that demands urgent medical care. Most often, liver failure occurs gradually and over many years. Rare condition known as acute liver failure occurs rapidly within 48hrs and difficult to detect initially.

Liver Regeneration

The liver has a remarkable capacity to regenerate after injury and to adjust its size to match its host. Within a week after partial hepatectomy, which, in typical experimental settings entails surgical removal of two-thirds of the liver, hepatic mass is back essentially to what it was prior to surgery.

Transplantation Biology

The science of transferring a graft from one part of the body to another or from one individual to another is known as Transplantation. The graft may consist of an organ, tissue, or cells. If donor and recipient are the same individual, the graft is autologous. If donor and recipient are genetically identical it is syngeneic. If donor and recipient are any other same-species individuals, the graft is allogeneic. If the donor and recipient are of different species, it is called xenogeneic.

Transplantation & Immunosuppressive Management

Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Transplantation Complications

Complications of a liver transplant can include rejection, an increased risk of infection, graft failure, biliary conditions and a higher risk of developing certain conditions – including some types of cancer.

Posttransplantation Care

After liver transplantation care must be taken because the complications don’t arise soon after the transplantation. They may arise after 2 or 3 weeks. Hence patients must be shifted to ICU and must be under observation. This is known as Post Transplantation care.

Journal of Liver: Disease & Transplantation is organizing & supporting a conference on World Congress on Hepatitis during July 20-22, 2015 at Florida, USA.

*Unofficial 2014 Impact Factor was established by dividing the number of articles published in 2012 and 2013 with the number of times they are cited in 2014 based on Google search and the Scholar Citation Index database. If ‘X’ is the total number of articles published in 2012 and 2013, and ‘Y’ is the number of times these articles were cited in indexed journals during 2014 than, impact factor = Y/X

Current Issue
Roles of Stearoyl-CoA Desaturase-1 in Hepatocellular Carcinoma   Editorial
Mark Kin-Fai Ma, Irene Oi-Lin NG and Terence Kin-Wah Lee
J Liver: Dis Transplant 2014, 3:2    doi: 10.4172/2325-9612.1000e107

Roles of Stearoyl-CoA Desaturase-1 in Hepatocellular Carcinoma

Metabolic deregulation is emerging as an important molecular hallmark for cancer cells, which is accompanied with increased of glycolysis and lipogenesis that fuel the tumor growth. During these processes, Stearoyl-CoA desaturase 1 (SCD1), a key enzyme in the lipogenesis pathway, has been recently drawn intensive attention in cancer research. SCD1, an enzyme that is located in the endoplasmic reticulum, is the major enzyme to catalyze the conversion of saturated fatty acid (SFA) to delta-9 MUFA.

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New Insights into the Molecular Mechanisms of Phthalate-Caused Hepatotoxicity: Novel Epigenetic Alterations   Editorial
Pinar Erkekoglu and Belma Koçer-Gümüşel
J Liver: Dis Transplant 2015, 4:1    doi: 10.4172/2325-9612.1000e108

New Insights into the Molecular Mechanisms of Phthalate-Caused Hepatotoxicity: Novel Epigenetic Alterations

Hepatocellular carcinoma (HCC) is one of the most frequent and life-threatening cancers and the most severe complication of chronic liver disease [1]. It represents approximately 85% of liver cancers. Its incidence is not only increasing worldwide in the past decade [2], but is also a leading cause of cancer-related deaths worldwide. Because most HCC cells display biochemical and morphological features of normal hepatocytes, it is assumed that HCC results from malignant transformation of normal hepatocytes, although a “stem cell” origin is also suspected [3]. Underlying liver injury, which leads to repeated cycles of inflammation, hepatocyte death (apoptotic/necrotic), and compensatory proliferation, is an ineluctable factor in the development of most HCCs.

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HEV Related Guillian-Barre’Syndrome: A Case Report   Research Article
Harshal Rajekar
J Liver: Dis Transplant 2015, 4:1    doi: 10.4172/2325-9612.1000126

HEV Related Guillian-Barre’Syndrome: A Case Report

HEV virus has been known to be a cause of fulminant hepatitis. Recently it has been suggested that HEV may have extra-hepatic manifestations, especially neurological, of which has been an AIDP (Acute Inflammatory Demyelinating Polyneuropathy) like syndrome i.e., Guillian Barre syndrome has been reported. A 19 year old male patient was admitted with fulminant hepatic failure with hepatic encephalopathy. The patient was electively intubated and treated for fulminant liver failure. As the patients encephalopathy improved, an ascending motor weakness that resolved over the next 3 weeks.

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Nonalcoholic Fatty Liver Disease (NAFLD) after Liver Transplantation: A Mini-Review   Review Article
Claudia P Oliveira, Mário R Alvares-da-Silva and Luiz A Carneiro D’Albuquerque
J Liver: Dis Transplant 2015, 4:1    doi: 10.4172/2325-9612.1000127

Nonalcoholic Fatty Liver Disease (NAFLD) after Liver Transplantation: A Mini-Review

Nonalcoholic fatty liver disease (NAFLD) encompasses a large spectrum of disease including simple steatosis, nonalcoholic steatohepatitis (NASH) and in some patients liver fibrosis, cirrhosis, liver failure and hepatocellular carcinoma. In the last few years NAFLD has became the most common liver disease in Western countries and has been recognized an important indication for the liver transplantation as well. Advances in medical therapy and surgical techniques have transformed the long-term survival of liver-transplant (LT) recipients. Currently metabolic syndrome and NAFLD recurrence or de novo NAFLD are common among LT NAFLD recipients since they present an increased risk of metabolic disturbances as a natural result of their personal characteristics.

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