Natural History and Virological Lessons from de novo HBV Infection in a Vaccinated Recipient of a Liver Graft from an Anti-HBc Positive Donor

Natural History and Virological Lessons from de novo HBV Infection in a Vaccinated Recipient of a Liver Graft from an Anti-HBc Positive Donor

de novo hepatitis B virus (HBV) infection in surface antigen (HBsAg)-negative liver transplant (LT) recipients, receiving fromHBsAg-negative and antibody to hepatitis B core antigen (anti- HBc)-positive donors was first described in 1994. It is now wellknown that transplantation from donors with serological evidence of a previous HBV infection is a major source of late reactivation of the virus.