Journal of Liver: Disease & TransplantationISSN: 2325-9612

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Case Report, J Liver Dis Transplant Vol: 2 Issue: 1

Natural History and Virological Lessons from de novo HBV Infection in a Vaccinated Recipient of a Liver Graft from an Anti-HBc Positive Donor

Veyer D1,2, Bardou-Jacquet E2,3,4, Legros L2,3,4, Lagathu G1, Guyader D2,3,4 and Colimon R1,2*
1CHU Rennes, Service de Virologie, F-35033, Rennes, France
2University Rennes1, UFR médecine, F-35043, Rennes, France
3CHU Rennes, Service des maladies du foie, F-35033, Rennes, France
4INSERM, U991, Hôpital Pontchaillou, F-35033, Rennes, France
Corresponding author : Ronald Colimon
University Rennes1, UFR médecine, F-35043, Rennes, France
Tel: +33299284276; Fax: +33299284159
E-mail: [email protected]
Received: November 02, 2012 Accepted: March 16, 2013 Published: March 20, 2013
Citation: Veyer D, Bardou-Jacquet E, Legros L, Lagathu G, Guyader D, et al. (2013) Natural History and Virological Lessons from de novo HBV Infection in a Vaccinated Recipient of a Liver Graft from an Anti-HBc Positive Donor. J Liver: Dis Transplant 2:1. doi:10.4172/2325-9612.1000106

Abstract

Natural History and Virological Lessons from de novo HBV Infection in a Vaccinated Recipient of a Liver Graft from an Anti-HBc Positive Donor

de novo hepatitis B virus (HBV) infection in surface antigen (HBsAg)-negative liver transplant (LT) recipients, receiving fromHBsAg-negative and antibody to hepatitis B core antigen (anti- HBc)-positive donors was first described in 1994. It is now wellknown that transplantation from donors with serological evidence of a previous HBV infection is a major source of late reactivation of the virus.

Keywords: Liver transplantation; de novo HBV-infection; HBsAg mutant; Anti- HBc; Prophylaxis

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