Advances in Photodynamic Therapy for Non-Melanoma Skin Cancers

Non-melanoma skin cancers (NMSC), primarily basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are among the most prevalent malignancies worldwide. Photodynamic therapy (PDT) has emerged as a minimally invasive alternative to surgery, offering targeted tumor destruction with excellent cosmetic outcomes. This review explores the principles of PDT, recent advancements in photosensitizer formulations, light delivery systems, and combination therapies. The advantages, limitations, and clinical success rates of PDT in NMSC management are discussed, along with future research directions aimed at improving efficacy and patient outcomes. Enhanced treatment specificity and reduced recurrence rates remain key goals in the field.