International Journal of Cardiovascular ResearchISSN: 2324-8602

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Assessment of the Relation between Average Aortic Valve Sclerosis Score Index and Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome

Objectives: The aim of this study was to assess the relation between average aortic valve (AV) sclerosis score index (AVSSI) and severity of coronary artery disease (CAD) in patients with acute coronary syndrome (ACS).

Patients and methods: A total of 100 patients with ACS were studied. They were classified into 2 equal groups of 50 patients each. Group (1) involved patients with average AVSSI>1 and group (2) involved patients with average AVSSI ≤ 1. They were matched in age and sex. For these patients electrocardiography (ECG), conventional echocardiography, coronary angiography and SYNTAX score were determined.

Results: The study found that there is a strong correlation between CAD and average AVSSI (r=0.791, p<0.001). There is increase in the incidence of average AVSSI with increase of CAD risk factors such as hypertension, diabetes mellitus, dyslipidemia, male gender, aging, family history, smoking, increased blood calcium and body mass index (BMI). Also there is decrease in LVEF % in group 1 (43.6 ± 7.14) compared to group 2 (51.2 ± 6.98) with statistically significant difference (p<0.001), while there is increase in E/e’ in group 1 (9.68 ± 3.58) compared to group 2 (5.68 ± 3.27), p<0.05. The prevalence of three-vessel CAD was higher in group 1 (24%) than in group 2 (8%), p<0.001. SYNTAX score was higher in average AVSSI>1 (16.4 ± 9.67) than average AVSSI ≤ 1 patients (8.82 ± 10.1), p<0.001.

Conclusion: It is concluded that there is a strong relationship between average AVSSI and severity of coronary artery disease, and is consistent with other high-risk echocardiographic findings.

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