Research Journal of Clinical Pediatrics

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Comparison of Heparin Solution and 0.9% Normal Saline Solution Flushing to Secure the Patency of Central Venous Catheters in Pediatrics patient

Purpose: The purpose of this study is to associate the efficiency of heparin and 0.9% normal saline solution blooming for preserving patency of central venous catheters in pediatrics patients.

Methods: A randomized controlled clinical trial was performed. Sxity-two (62) patients were prospectively enrolled and were completed the study. The heparin group consisted of 31 patients given 10u/ml (below 10kg) or 100u/ml diluted heparin flushing and the normal saline group consisted of 31 patients with 0.9% sodium chloride flushing.

Results: There was no significantly difference in occlusion between the heparin group and the normal saline group in central venous catheters’ occlusion. Also there was no difference between these two groups in catheterrelated infections.

Conclusion: Flushing with 0.9% normal saline is as effective as flushing with heparin solution in maintaining the patency of central venous catheters. In this study, however, the duration of central line use was difference and the infection occurrence was little. Further studies are warranted with a larger sample size at multiple centers.

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