Diagnostic Value of Low Density Lipoprotein 4 in Patients with Documented Coronary Artery Disease

Background: Hyperlipidemia is a well-established risk factor for Coronary Artery Disease (CAD). Small dense LDL particle subtypes (LDL 3 and LDL 4) have been observed to be more oxidizable and atherogenic. We aimed to identify the role of cholesterol particle subtypes in predicting CAD severity. Objective: The aim of this study was to identify novel biomarker (LDL 4) to predict severity of CAD on extended lipid profile compared to traditional cholesterol measurements. Methods: This is a cross sectional study which was conducted on 100 CAD patients admitted for elective coronary angiography. All patients were subjected to detailed history, physical examination, electrocardiography, echocardiography, laboratory investigations including total and differential cholesterol measurement and elective coronary angiography. Conclusion: Cholesterol subtype (LDL 4) is significantly correlated with severity of coronary artery disease. It is also a strong independent predictor of severity of CAD than traditional cholesterol measurements.