Endocrinology & Diabetes ResearchISSN: 2470-7570

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Hypoxia Inducible Factor-1α Gene rs11549465 Might be Protective Factor for the Development of Type 1 Diabetes Mellitus

Introduction: Pancreas is a highly vascularized tissue which makes oxygen a fundamental element for its metabolism. As a consequence of the variations in its delivery, the expression of genes that maintain homeostatic levels of oxygen supply a regulated by hypoxia-inducible factor 1 α (HIF-1α). Here we tested the role of single nucleotide polymorphism (SNP) of HIF-1α as markers for susceptibility or protection to develop pancreatic injury in Mexican patients with type 1 diabetes mellitus (T1DM).
Methods: We studied 55 patients with T1DM that conformed to the criteria of the American Diabetes Association (ADA); in them, we extracted DNA from peripheral blood cells and studied the gene that encodes HIF-1α. The SNP selection was done in accordance to the SNP database (https://www.ncbi.nlm.nih.gov/SNP/). Three polymorphisms were included: rs11549465, rs11549467 and rs2057482. Statistical analysis was performed by the EpiInfo statistical program (version 6), using p<0.05 as the level as statistical significance; gene frequencies were compared to those present in 66 healthy ethnically matched individuals.
Results: We observed in patients a significant decreased frequency of the polymorphism rs11549465 as compared to the group of healthy controls (p=0.0018; OR=0.07 [0.0-0.48]). We observed a change in the domain oxygen dependent degradation domain “ODDD” which converts Pro-582 to Ser.
Conclusion: The T allele of the polymorphism rs11549465 seems to be a protective factor for the development of T1DM.

Special Features

Full Text


Track Your Manuscript

Media Partners