Andrology & Gynecology: Current ResearchISSN: 2327-4360

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Microfluidic Device Increases Sperm Concentration by Optimization of Chamber Structure

Microfluidic Device Increases Sperm Concentration by Optimization of Chamber Structure

Intracytoplasmic sperm injection (ICSI) is an extremely timeconsuming and tedious procedure in cases of oligozoospermia, because it is difficult to obtain a sufficient number of motile sperms. To circumvent this difficulty, we previously developed a microfluidic device to increase sperm concentration and reduce time required for ICSI. Here, we improved this device by carefully optimizing its dimensions. We achieved a 10–13-fold enrichment ratio in non-motile human sperms (1.0 × 104 cells/ml) when a chamber height of 1.4 mm was used, and we described a mathematical model to explain the relationship between sperm concentration and enrichment ratio. However, this model was unable to explain the decrease in the enrichment ratio when a chamber height of 1 mm was used.

Special Features

Full Text

View

Track Your Manuscript

Media Partners

GET THE APP