Pivotal Role of Aβ Amyloidosis in the Pathogenesis of Alzheimer's Disease, Cerebral Amyloid Angiopathy, and Lobar Haemorrhages: An Indication for Routine Plasma Aβ42/40 Ratio Screening in Trisomy 21

Aβ amyloidosis plays a pivotal role in the development of Alzheimer's disease, cerebral amyloid angiopathy, and lobar hemorrhages all of which have severe neurological consequences. Association between trisomy 21 and Aβ amyloidosis has been established posing patients with trisomy 21 risk of developing Alzheimer's disease, cerebral amyloid angiopathy, and lobar hemorrhages. Early detection of evidence Aβ amyloidosis in these patients will be very helpful in the management and overall outcome of such diseases. Research has shown the correlation between plasma or CSF Aβ42/40 ratio and Aβ amyloidosis, screening for plasma Aβ42/40 ratio in patients with trisomy 21 will aid in early detection of Aβ amyloidosis and secondary prevention of Alzheimer’s disease, cerebral amyloid angiopathy and lobar hemorrhages in those patients.