The Association between Serum Uric Acid Level and Hematological parameters in Healthy Chinese Adults

Background: A definite and uniform standard concerning urate lowering therapy for hyperuricemic patients with different risks is lacking. It is important to identify simple and available clinical indicators to assess the risk of hyperuricemia and guide stratified treatment. The aim of the present study was to explore the association of serum Uric Acid (UA) levels with hematological parameters in healthy Chinese adults.

Case Presentation: In this retrospective study, 657 Chinese adults (447 males, 210 females) who underwent health check-up Huadong hospital affiliated to Fudan University in Shanghai, China were sampled. males, females and postmenopausal females older than 50 years (called female subgroup) were divided into three tertiles according to serum UA respectively. Clinical characteristics and hematological parameters were compared in different UA tertiles. Correlation and multiple regression analysis were used to investigate the relationship of UA with hematological parameters.

Results: After adjusting for potential confounding factors, serum UA was positively associated with RBC count, Hb and HCT in males. Serum UA was positively associated with MPV in females and postmenopausal females. RBC count, Hb and HCT were significantly higher in UA3 than that in UA1 in males. MPV was significantly higher in UA3 than that in UA1 in all females and postmenopausal females.

Conclusion: Our study demonstrated that serum UA was positively associated with RBC count, Hb and HCT in Chinese male adults and positively associated with MPV in Chinese female adults and postmenopausal females. Gender differences in the association between serum UA and MPV may not be related to estrogen levels. RBC count, Hb, HCT and MPV might assess the risk of hyperuricemia and guide stratified treatment.