The Use of Topical Amphotericin Nasal Packing for Invasive Fungal Sinusitis in an Adolescent Patient

Acute Invasive Fungal Sinusitis (IFS) can be difficult to control,with surgical debridement playing the primary role in treatment. Here we present a novel adjunctive treatment of IFS with topical anti-fungal nasal packing. A 15-year-old female underwent multiple extensive endo nasal debridements with persistent fungal elements. Due to the risk of nasal deformity with further debridement, amphotericin B soaked in dissolvable foam was applied topically within the nose as an adjunct to surgical and intravenous therapy. Pathology after initiation of amphotericin nasal packing was negative for fungal elements on all sites. Patient has not had disease recurrence at 6 months.