Endocrinology & Diabetes ResearchISSN: 2470-7570

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Tryptophan Metabolism- Indoleamine 2,3-Dioxygenase- Friend and Foe

Tryptophan Metabolism- Indoleamine 2,3-Dioxygenase- Friend and Foe

Indoleamine 2,3-dioxygenase (IDO) (EC 1.13.11.42) is a cytoplasmic, heme-containing enzyme that mediates the initial and rate-limiting step in the oxidative catabolism of the essential amino acid L-tryptophan (L-Trp). Recently, an additional IDO molecule, termed IDO2 has been identified. The gene encoding IDO2 is adjacent to the IDO gene. The IDO2 protein has a different expression profile to IDO and while it is able to metabolize L-Trp, IDO2 has a much higher Km for this substrate. In addition both enzymes differ in their selectivity for some inhibitors. Degradation of L-Trp via IDO leads to the production of several metabolites, including N-formyl-kynurenine and Kynurenine (Kyn).

Special Features

Full Text

View

Track Your Manuscript

Share This Page

Media Partners

Associations