Unilateral Giant Lung Bulla: Placental transmogrification should be in Mind

Placental transmogrification is a peculiar clinical entity of the lung of uncertain etiology. We report two cases of pulmonary placental transmogrification in two patients of different nationalities. Both of them have no history of smoking or chronic lung disease. The main presentations were dyspnea and chest pain. Radiologic studies showed unilateral giant bulla in both patients; additional pneumothorax was present in only one patient. They were subjected to surgical bullectomy. Histopathologic studies revealed the presence of intracystic placenta like villous structures and a diagnosis of placental transmogrification was made. Placental transmogrification should be considered in cases of unilateral bullae.