Journal of Genetics and Gene Therapy

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Use of porcine bladder matrix in chronic wounds and its relationship to macrophage phenotype

UBM technology facilitates remodeling through a decellularized extracellular matrix (ECM) that contains an intact epithelial basement membrane (BM) and subjacent lamina propria. The BM contains components of collagen, fibronectin, laminin and growth factors that facilitate angiogenesis and proliferation of functional connective tissue. A single site large prospective case series is currently being conducted at our center and the preliminary results will be presented. Preliminary data suggest single-layer sheet and micronized UBM to be a useful option for partial thickness. wound closure. Venous ulcers were found to have the highest incidence of complete wound closure. Minimal side effects were seen with UBM in the interim analysis. Preliminary results indicate treatment with UBM may correlate with a shift to an anti-inflammatory macrophage population.

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