Journal of Virology & Antiviral Research.ISSN: 2324-8955

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Virome of children with acute gastroenteritis identified a novel human adenovirus C type with a chimeric hexon gene

Human Adenovirus species C (HAdV-C) are the most common etiologic agents of respiratory disease. In the present study we characterized the nearly full-length genome of one potential new HAdV-C recombinant strain constitute by Penton and Fiber proteins belonging to type 89 and a chimeric Hexon protein of type 1 and 89. By using viral metagenomics techniques, we screened out, in the state of Tocantins, North Brazil, from 2010 to 2016, 251 fecal samples of children between 0.5 to 2.5-year-old. These children were presenting acute diarrhea not associated with common pathogens (i.e. rotavirus, norovirus). We identified two HAdV-C strains in two distinct patients. Phylogenetic analysis performed using all complete genomes available at GenBank database indicated that one strain (HAdV-C BR-245) belongs to the type 1. The phylogenetic analysis also indicated that the second strain (HAdV-C BR-211) was located at the base of the clade formed by the newly HAdV-C strains type 89. Recombination analysis revealed that strain HAdV-C BR-211is a chimera in which the variable regions of Hexon gene combined HAdV-C1 and HAdV-C89 sequences. Therefore, HAdV-C BR-211 strain possess a genomic backbone of type HAdV-C89 and a unique insertion of HAdV-C1 in the Hexon sequence. Recombination may play an important driving force in HAdV-C diversity and evolution. Studies employing complete genomic sequencing on circulating HAdV-C strains in Brazil are needed to understand the clinical significance of the presented data.

Special Features

Full Text

View

Track Your Manuscript

Recommended Conferences

Share This Page

Media Partners

Associations