Cell Biology: Research & TherapyISSN: 2324-9293

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Research Article, Cell Biol Res Ther Vol: 4 Issue: 2

Antioxidant-Dependent Prevention of H2O2-Induced Premature Senescence in Human Endometrial Stem Cells

Alla N Shatrova1, Aleksandra V Borodkina 1, Nikolay N Nikolsky1,2 and Elena B Burova1*
1Department of Intracellular Signaling and Transport, Institute of Cytology, Russian Academy of Sciences, St Petersburg, Russia
2Department of Medical Physics, St Petersburg State Polytechnical University, St Petersburg, Russia
Corresponding author : Elena B. Burova
Department of Intracellular Signaling and Transport, Institute of Cytology, Russian Academy of Sciences, St Petersburg, Russia
Tel: +7 812 2974596
E-mail: [email protected]
Received: July 06, 2015 Accepted: August 08, 2015 Published: September 04, 2015
Citation: Shatrova AN, Borodkina AV, Nikolsky NN, Burova EB (2015) Antioxidant-Dependent Prevention of H2O2-Induced Premature Senescence in Human Endometrial Stem Cells. Cell Biol: Res Ther 4:1. doi:10.4172/2324-9293.1000118

Abstract

Human endometrium-derived mesenchymal stem cells (hMESC) undergo the premature senescence in response to sublethal H2O2 doses what may complicate their successful transplantation into recipients with age-related disorders accompanied by increased levels of oxidative stress. Therefore, basic research is needed to improve and develop new therapeutic strategies based on the stem cell prevention from premature senescence in oxidative stress conditions. The effects of antioxidants on hMESC remain as yet unexplored. The present study aimed to evaluate an ability of antioxidants, N-acetyl-Lcysteine (NAC) and diphenylene iodonium (DPI) to prevent H2O2-induced premature senescence of hMESC

Keywords: NAC; DPI; Mesenchymal stem cells; ROS; Premature senescence; Antioxidants

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