Abdel-Moneim M Osman Author

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Lindane Induces Spermatotoxicity and inhibits Steroidogenesis in Adult Rats

Author(s):

Hamdy AA Aly, Abdulrahman M Alahdal, Alaa Bagalagel, Ahmed M Mansour, Abdel-Moneim M Osman,Ibrahim A Shehata and Waleed El-Shaer

This study was conducted to investigate the influence of lindane on spermatogenesis and testicular biochemical parameters and to get insight into its mechanism. Adult male albino rats were treated orally with lindane at doses of 0, 1, 2 or 4 mg/kg/day for 30 consecutive days. Testes weight and sperm count and motility were significantly decreased. Testicular activities of 3β-HSD, 17β-HSD were significantly inhibited. Testicular cholesterol level was significantly increased while glycogen and sialic acid content were significantly decreased. Testicular activities of LDH-X, γ-GT, β-glucuronidase and acid phosphatase (ACP) were significantly decreased. Aldo-ketoreductase activity was significantly decreased in response to 2 or 4 mg/kg/day o... view more»

DOI: 10.4172/2327-4360.1000150

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