Abdulrahman Al-Asmari Author

Special Issue Article Open Access

Association of inducible nitric oxide synthase (iNOS) gene promoter polymorphism with vitiligo susceptibility in Saudis

Author(s):

Abdulrahman Al-Asmari

Vitiligo is an acquired, immune system skin issue described by melanocyte misfortune coming about into dynamic depigmentation of skin and hair. Vitiligo commonly shows familial aggregation and multifactorial mode of inheritance. It is a polygenic disease and several genes related to oxidative stress have been associated with the pathogenesis of vitiligo. The present study was aimed to investigate any possible association of inducible nitric oxide synthase (iNOS) gene polymorphisms (iNOS 954 G/C and iNOS Ex16+14 C/T) with vitiligo in Saudis. This study includes 120 vitiligo cases and 120 healthy matched controls. Polymerase chain reaction with restriction fragment length polymorphism method was used for the analysis of genetic polymorphisms. The ... view more»

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