Adam Kellner Author

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Is Metothrexate so Harmless in Patients with Autoimmune Disorders?

Author(s):

Adam Kellner, Vasana S Kellner, Eva Karadi Balazs Kollar and Miklos Egyed

The incidence of autoimmune diseases increasing nowdays. Despite of the development of diagnosis and management of diseases, they remained chronic diseases. The patient’s lifespan expansion requires long-term treatment with harmful agents, such as Metothrexate or other immunosuppressive drugs. The Metothrexate toxicities are based on the duration and cumulative dosing of drug, and the combination with other drugs. Myelosuppression and consequent pancytopenia is the most frequent hematologic toxicity, which occur mostly later during low dose Metothrexate administration. We demonstrate three cases of low dose metothrexate toxicity in older patients with rheumatoid arthritis and psoriasis. All patients were treated with low dose Metothrexate along more than one year continuously. Two... view more»

DOI: 10.4172/2324-9110.1000202

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