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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Adel Mutahar Author
Subjects of specialization
Affiliation
Colorectal cancer, Cancer chemotherapy, Prostate biomarker, Endometrial cancer
Department of Studies in Biotechnology, Molecular Oncology Lab, University of Mysore, Manasagangotri, Mysore, Karnataka, India
Biography
Adel Mutahar was working in the Department of Studies in Biotechnology, Molecular Oncology Lab, University of Mysore, Manasagangotri, Mysore, Karnataka, India. He has more than 40 publications. His current research area related to osteoarthropathy.
Publications
Research Article Subscription
Antiangiogenic Activity of rTRAIL is Potentiated by Sflt-1, a VEGF Trap
Author(s): Yashaswini B, Adel Mutahar and Bharathi P Salimath
Objective: Anti-angiogenesis and pro-apoptosis are the two processes which are strategically used to target tumors. The soluble form of VEGF receptor 1 (Flt-1) is a modulator of VEGF activity and could be useful as a trap to intrinsically sequester VEGF in tumor cells. In the present study, we have investigated the role of rTRAIL in inhibiting VEGF-mediated angiogenesis and its synergistic potentiation by sFlt-1.
Methods: We have expressed human recombinant TRAIL, to study its role in anti-angiogenesis and a 2-domain active variant of sFlt-1 by bacterial expression to be used as a trap for VEGF. 3[H] thymidine incorporation assay was used to confirm the inhibitory activity of sFlt-1 and/or rTRAIL on cell proliferation. Th... view more»
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