Aditi Karanth Author

Research Article Open Access

Caffeine Induces Significant Higher Protein Activity for Cell Activation and Lower Carboxyl Esterase Activity in Male Wistar Rat’s Brain and Liver

Author(s):

Prabha M, Aditi Karanth, Neethu P, Vaishnavi Ramesh and Suneetha P

Specific activity of carboxyl esterase was estimated with and without caffeine on young and old aged wistar rat’s brain and liver. Carboxyl esterase (CE) is categorized as phase-I drug metabolizing enzyme that hydrolyzes carboxylic acid esters, amides and thioesters. Total Protein and CE was estimated with 3 and 6 days caffeine treated (daily dose of stock 13mg/kg) young and old male wistar rat’s brain and liver (each n=5) as compared to control. Histogram showed significantly higher protein 123.31 mg and 100.57 mg respectively for 3 and 6 days caffeine treated old rats’ brain than their control 47.72 mg of protein. While young brain caffeine treated showed higher 70.80 mg and 72.89 mg respectively than control 52.07 mg. Electrophoresis sho... view more»

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