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Hindi International Journal of Cardiovascular ResearchISSN: 2324-8602
Aleksandra Niedzwiecki Author
Subjects of specialization
Affiliation
Vitamin C, Lipoprotein(a)
Aleksandra Niedzwiecki Dr Rath Research Institute, Santa Clara, CA 95050, USA
Biography
Aleksandra Niedzwiecki
Dr Rath Research Institute, Santa Clara, CA 95050, USA, his skills are Angiogenesis, Clinical Trials, Nutritional Biochemistry, Cancer Cell Line, Metastasis, latest publication is Simultaneous Inhibition of SARS-CoV-2 Infectivity by a Specific Combination of Plant-derived Compounds.
Publications
Research Article Open Access
Cardiovascular Effects of Cyclical Dietary Vitamin C Withdrawal in Mice Deficient in Internal Synthesis Vitamin C and producing human lipoprotein (a): Gulo(-/-); Lp(a)+
Author(s): Lei Shi, Aleksandra Niedzwiecki*, Vadim Ivanov and Matthias Rath
Background: Scientific knowledge of the impact of periodic dietary vitamin C intake and withdrawal on the development of cardiovascular disease has been limited. Our earlier study using a transgenic Gulo(-/-); Lp(a)+ mouse model mimicking human metabolism in respect to a lack of internal synthesis of vitamin C and expression of human lipoprotein (a) [Lp(a)], a recognized risk factor for cardiovascular disease, showed that vitamin C deficiency triggers vascular deposition of Lp(a) and atherosclerosis. In this study we used this mouse model to investigate the effect of cyclical vitamin C withdrawal and its continuous supplementation on metabolic factors related to cardiovascular health, such as lipid profile and vascular plaque development.
Methods:view more»
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