Alfred Ketcham Author

Research Article Open Access

Intratumoral Therapy II: In Vitro and In Vivo Immunologic Testing and Therapy Options

Author(s):

Max Cohen*, Alfred Ketcham and Ronald Herberman

In a prospective randomized trial in patients with metastatic melanoma we compared two agents that had been used for metastatic melanoma intratumoral injections. Each patient had progressive metastatic disease no longer surgically controllable. Multiple metastases included satellitosis in the form of progressive nodules around the previously excised original melanoma site, and/or in-transit metastases in the form of observable tumor nodules progressing in a linear fashion toward a lymph node bearing area. As patients were receiving intratumoral injections, serially collected blood samples were tested for general immunologic reactivity and anti-melanoma reactivity. Specificity controls included breast cancer and lung cancer extracts.

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DOI: 10.4172/2324-9110.1000222

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