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Hindi Journal of Molecular Biology and Methods
Aliyu Adamu Author
Subjects of specialization
Affiliation
Gel Electrophoresis,Cloning,DNA Extraction,RNA Extraction,Molecular Microbiology
Faculty of Science, Department of Microbiology, Kaduna State University, Tafawa Balewa way, Kaduna PMB 2339, Nigeria
Biography
Aliyu Adamu Faculty of Science, Department of Microbiology, Kaduna State University, Tafawa Balewa way, Kaduna PMB 2339, Nigeria, His Research Interest is " Gel Electrophoresis Cloning DNA Extraction RNA Extraction Molecular Microbiology Real-Time PCR Molecular Dynamics Simulation Homology Modeling Protein Structure"
Publications
Review Article Open Access
Molecular Basis and Engineering of Enzymes Stereospecificity
Author(s): Aliyu Adamu, Firdausi Aliyu, Fahrul Huyop and Roswanira Abdul Wahab
Molecular recognition, particularly enantiomeric specificity of biological molecules is a key consideration in designing drugs, pharmaceutical intermediate and in industrial production of chirally active intermediate. Although the molecular bases of many enzymes stereospecificity are not completely delineated, a number of protein engineering studies were able to enhance and even in some cases invert the stereospecificity of various enzymes. Herein, we review the current understanding on enzymes stereospecificity, and the effects of mutations to the stereospecific pockets due to enzymes engineering to improve stereospecificity.
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