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Hindi Endocrinology & Diabetes ResearchISSN: 2470-7570
Amanda E Brandon Author
Subjects of specialization
Affiliation
Massachusetts
Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control
Biography
Brigham and Women's Hospital, Harvard Medical School, Massachusetts General Hospital, Schizophrenia International Research Society, University of North Carolina at Chapel Hill, Wake Forest University University of North Carolina at Chapel Hill, Wake Forest University
Publications
Research Article Subscription
Distinct Changes in Adipose Tissue and Muscle in Response to Excess Systemic Glucose in Rats
Author(s): X Julia Xu1, Amanda E Brandon, Ella Stuart, Kaajal Patel1, Reyhan Gedik1, Asish Saha1, Edward W Kraegen and Neil B Ruderman1
Objective: Excess nutrients can cause insulin resistance in skeletal muscle in vivo. However, the response of white adipose tissue is less clear. In a chronic glucose infusion model (1 and 4 days), distinct adaptations in muscle and white adipose tissue have been described. Muscle developed sustained insulin resistance after 1 day of glucose infusion but adipose tissue did not. Exactly what distinguishes adipose tissue from muscle in response to glucose oversupply remains to be determined. The aim of the present study was to investigate the early (3-8 h) metabolic and signaling changes that take place in epididymal fat pads, and to a lesser extent, red... view more»
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