Amr M Abdelhamid | Author | SciTechnol | Endocrinology & Diabete

Amr M Abdelhamid Author

aabdelhamid@msa.eun.eg +01001425902 | +01001425902

Subjects of specialization
Metformin, Vitamin B12, Liver cells, HepG2 culture

Affiliation
Biochemistry Department, Faculty of Pharmacy, Modern Sciences and Arts University, Cairo, Egypt

Biography

Amr M Abdelhamid Biochemistry Department, Faculty of Pharmacy, Modern Sciences and Arts University, Cairo, Egypt. His publications include: 1.Shaw JE, Sicree RA, Zimmet PZ (2010) Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87: 4-14. 2.Tilg H, Moschen AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6: 772-783.

Publications

Research Article Open Access

Association of Apelin Genetic Variants with Type Two Diabetes Mellitus in Egyptian Population

Author(s):

Sherine M Ibrahim, Mohamed M Hafez, Amr M Abdelhamid

Abstract Background and Aim: Apelin, the newly identified adipokine and the endogenous ligand for the APJ receptor is related to obesity and insulin resistance. The aim of the study was to investigate the association of 2 single-nucleotide polymorphisms (SNPs) in the apelin gene (APLN) with susceptibility to Type Two Diabetes Mellitus (T2DM) in the Egyptian population. Methods: Two SNPs on APLN were genotyped in 145 diabetic patients and 135 nondiabetic individuals, aged 40-60 years. Realtime polymerase chain reaction (RT-PCR) was used to analyze the 2 SNPs in both the diabetic and the healthy subjects. The association of the 2 SNPs (rs2281068 and rs3115759) in APLN and T2DM risk was investigated. Allele and genotype frequen... view more»

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