Analiacute;a Berinstein Author

Research Article Open Access

Effect of Different Routes of Inoculation on Plant-Derived VP2 Immunogenicity and Ability to Confer Protection Against Infectious Bursal Disease

Author(s):

María Soledad Lucero, Evangelina Gomez, Matías Richetta, Silvina Chimeno Zoth,Juan Manuel Carballeda, María José Gravisaco, Fernando Delgado and Analía Berinstein

Infectious Bursal Disease Virus (IBDV) is the etiological agent of an immunosuppressive and highly contagious disease that affects young birds causing important economic losses in the poultry industry. The structural protein VP2 has been used for the development of subunit vaccines in a variety of heterologous platforms. We have previously demonstrated that plant-derived VP2 (pVP2) is able to elicit a neutralizing antibody response in chickens when administered intramuscularly (i.m.) in a prime/boost scheme. However, administration via injection is impractical and carries the risk of needle stick injury or pain. Mucosal vaccination is noninvasive and has several advantages over traditional systemic vaccines. Taking this into account and the fact that natural... view more»

DOI: 10.4172/2324-8955.1000161

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