Andrea Bernini Author

Short Communication Open Access

Identification of Inhibitors Binding Site of Ebola L Polymerase Based on its Homology Model

Author(s):

Alfonso Trezza, Andrea Bernini and Ottavia Spiga

This paper describes methods, results and conclusions about our study regarding the development and the optimization of a homology model of Ebola virus RNAdependent RNA polymerase, also called L polymerase, based on crystal structure of Vesicular stomatitis virus L polymerase. L polymerase is an essential protein for the outliving of virus; for this reason it is used as target for antiviral therapy. The aim of this work was to study the three-dimensional model of Ebola virus L polymerase and its inhibitors adopting a computational approach. We used docking simulation and multi-aligned L protein sequences in order to identify the potential binding pocket of inhibitors and their drug ability against Ebola virus L protein. Based on a dataset of ten validated mo... view more»

DOI: 10.4172/2324-8955.1000162

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