Asish Saha1 Author

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Distinct Changes in Adipose Tissue and Muscle in Response to Excess Systemic Glucose in Rats

Author(s):

X Julia Xu1, Amanda E Brandon, Ella Stuart, Kaajal Patel1, Reyhan Gedik1, Asish Saha1, Edward W Kraegen and Neil B Ruderman1

Objective: Excess nutrients can cause insulin resistance in skeletal muscle in vivo. However, the response of white adipose tissue is less clear. In a chronic glucose infusion model (1 and 4 days), distinct adaptations in muscle and white adipose tissue have been described. Muscle developed sustained insulin resistance after 1 day of glucose infusion but adipose tissue did not. Exactly what distinguishes adipose tissue from muscle in response to glucose oversupply remains to be determined. The aim of the present study was to investigate the early (3-8 h) metabolic and signaling changes that take place in epididymal fat pads, and to a lesser extent, red... view more»

DOI: 10.4172/2470-7570.1000106

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